Effect of Antiorthostatic Hypokinesia on the Pharmacokinetics and Bioavailability of Propranolol
- Авторы: Kondratenko S.1, Kovachevich I.2, Repenkova L.2
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Учреждения:
- I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
- Institute of Biomedical Problems, State Research Center of the Russian, Federation, Russian Academy of Sciences
- Выпуск: Том 52, № 6 (2018)
- Страницы: 491-494
- Раздел: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/245270
- DOI: https://doi.org/10.1007/s11094-018-1845-y
- ID: 245270
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Аннотация
The pharmacokinetics of propranolol were studied in healthy volunteers after a single peroral administration at a dose of 80 mg under normal conditions, on the second day of antiorthostatic hypokinesia, and on the first day after termination of the hypokinesia. The maximum propranolol concentration (–6 ∆%), area under the pharmacokinetic curve (–13 ∆%), elimination half-life (–15 ∆%), mean residence time in the body (–17 ∆%), and distribution volume (–8 ∆%) tended to decrease with antiorthostatic hypokinesia whereas the total clearance (+13 ∆%), ratio of maximum concentrations (125 ± 23%), and relative absorption rate of the drug (158 ± 48%) increased.
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S. Kondratenko
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Автор, ответственный за переписку.
Email: snko@mail.ru
Россия, 8/2 Trubetskaya St., Moscow, 119991
I. Kovachevich
Institute of Biomedical Problems, State Research Center of the Russian, Federation, Russian Academy of Sciences
Email: snko@mail.ru
Россия, 76A Khoroshevskoe Shosse, Moscow, 123007
L. Repenkova
Institute of Biomedical Problems, State Research Center of the Russian, Federation, Russian Academy of Sciences
Email: snko@mail.ru
Россия, 76A Khoroshevskoe Shosse, Moscow, 123007