Effect of Antiorthostatic Hypokinesia on the Pharmacokinetics and Bioavailability of Propranolol
- Authors: Kondratenko S.N.1, Kovachevich I.V.2, Repenkova L.G.2
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Affiliations:
- I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
- Institute of Biomedical Problems, State Research Center of the Russian, Federation, Russian Academy of Sciences
- Issue: Vol 52, No 6 (2018)
- Pages: 491-494
- Section: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/245270
- DOI: https://doi.org/10.1007/s11094-018-1845-y
- ID: 245270
Cite item
Abstract
The pharmacokinetics of propranolol were studied in healthy volunteers after a single peroral administration at a dose of 80 mg under normal conditions, on the second day of antiorthostatic hypokinesia, and on the first day after termination of the hypokinesia. The maximum propranolol concentration (–6 ∆%), area under the pharmacokinetic curve (–13 ∆%), elimination half-life (–15 ∆%), mean residence time in the body (–17 ∆%), and distribution volume (–8 ∆%) tended to decrease with antiorthostatic hypokinesia whereas the total clearance (+13 ∆%), ratio of maximum concentrations (125 ± 23%), and relative absorption rate of the drug (158 ± 48%) increased.
About the authors
S. N. Kondratenko
I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: snko@mail.ru
Russian Federation, 8/2 Trubetskaya St., Moscow, 119991
I. V. Kovachevich
Institute of Biomedical Problems, State Research Center of the Russian, Federation, Russian Academy of Sciences
Email: snko@mail.ru
Russian Federation, 76A Khoroshevskoe Shosse, Moscow, 123007
L. G. Repenkova
Institute of Biomedical Problems, State Research Center of the Russian, Federation, Russian Academy of Sciences
Email: snko@mail.ru
Russian Federation, 76A Khoroshevskoe Shosse, Moscow, 123007