Quantitative Determination of Mycophenolic Acid in Human Blood Plasma by High-Performance Liquid Chromatography with Tandem Mass-Spectrometric Detection
- Авторы: Khokhlov A.1,2, Dzhurko Y.2, Shitov L.1,2, Kubeš V.2, Ryska M.2, Yaichkov I.1,2, Shitova A.2, Shabrov V.2, Miroshnikov A.1
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Учреждения:
- Yaroslavl State Medical University, Ministry of Public Health of the Russian Federation
- Quinta-Analytica Yaroslavl Co.
- Выпуск: Том 51, № 6 (2017)
- Страницы: 504-507
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244678
- DOI: https://doi.org/10.1007/s11094-017-1643-y
- ID: 244678
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Аннотация
A new rapid and accurate method for determining the mycophenolic acid concentration in human blood plasma using HPLC with tandem mass-spectrometric detection (HPLC-MS/MS) and deproteinization for sample preparation was developed. The method was validated according to the Guideline for Validation of Bioanalytical Methods of EMEA and Guidelines for Examination of Drugs. This method was used to study the pharmacokinetics of mycophenolate sodium.
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Об авторах
A. Khokhlov
Yaroslavl State Medical University, Ministry of Public Health of the Russian Federation; Quinta-Analytica Yaroslavl Co.
Email: chem@folium.ru
Россия, 5 Revolyutsionnaya St, Yaroslavl, 150000; 52 Leningradskii Prosp, Yaroslavl, 150045
Yu. Dzhurko
Quinta-Analytica Yaroslavl Co.
Email: chem@folium.ru
Россия, 52 Leningradskii Prosp, Yaroslavl, 150045
L. Shitov
Yaroslavl State Medical University, Ministry of Public Health of the Russian Federation; Quinta-Analytica Yaroslavl Co.
Email: chem@folium.ru
Россия, 5 Revolyutsionnaya St, Yaroslavl, 150000; 52 Leningradskii Prosp, Yaroslavl, 150045
V. Kubeš
Quinta-Analytica Yaroslavl Co.
Email: chem@folium.ru
Россия, 52 Leningradskii Prosp, Yaroslavl, 150045
M. Ryska
Quinta-Analytica Yaroslavl Co.
Email: chem@folium.ru
Россия, 52 Leningradskii Prosp, Yaroslavl, 150045
I. Yaichkov
Yaroslavl State Medical University, Ministry of Public Health of the Russian Federation; Quinta-Analytica Yaroslavl Co.
Email: chem@folium.ru
Россия, 5 Revolyutsionnaya St, Yaroslavl, 150000; 52 Leningradskii Prosp, Yaroslavl, 150045
A. Shitova
Quinta-Analytica Yaroslavl Co.
Email: chem@folium.ru
Россия, 52 Leningradskii Prosp, Yaroslavl, 150045
V. Shabrov
Quinta-Analytica Yaroslavl Co.
Email: chem@folium.ru
Россия, 52 Leningradskii Prosp, Yaroslavl, 150045
A. Miroshnikov
Yaroslavl State Medical University, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Россия, 5 Revolyutsionnaya St, Yaroslavl, 150000