Development and Validation of an HPLC Method with Mass Spectrometric Detection for Quantitative Determination of Chlormadinone Acetate and Ethinyl Estradiol in Human Blood Plasma
- Авторы: Gil’deeva G.1, Belostotskii A.1, Sapozhnikova D.2
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Учреждения:
- Sechenov First Moscow State Medical University
- MDA Ltd.
- Выпуск: Том 51, № 2 (2017)
- Страницы: 142-152
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244520
- DOI: https://doi.org/10.1007/s11094-017-1573-8
- ID: 244520
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Аннотация
An HPLC method with mass-spectrometric detection was developed for simultaneous quantitative determination of chlormadinone acetate and ethinyl estradiol in human blood plasma. The sample preparation method included liquid—liquid extraction using hexane—Et2O. The method was validated for selectivity, linearity, accuracy, precision, cross-transfer, and stability. The developed method enabled simultaneous determination of the chlormadinone acetate and ethinyl estradiol blood concentrations in volunteers and could be used for pharmacokinetics studies.
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Об авторах
G. Gil’deeva
Sechenov First Moscow State Medical University
Email: dsapozhnikova@mail.ru
Россия, Moscow, 128018
A. Belostotskii
Sechenov First Moscow State Medical University
Email: dsapozhnikova@mail.ru
Россия, Moscow, 128018
D. Sapozhnikova
MDA Ltd.
Автор, ответственный за переписку.
Email: dsapozhnikova@mail.ru
Россия, Moscow