Development and Validation of an HPLC Method with Mass Spectrometric Detection for Quantitative Determination of Chlormadinone Acetate and Ethinyl Estradiol in Human Blood Plasma
- Авторлар: Gil’deeva G.1, Belostotskii A.1, Sapozhnikova D.2
-
Мекемелер:
- Sechenov First Moscow State Medical University
- MDA Ltd.
- Шығарылым: Том 51, № 2 (2017)
- Беттер: 142-152
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244520
- DOI: https://doi.org/10.1007/s11094-017-1573-8
- ID: 244520
Дәйексөз келтіру
Аннотация
An HPLC method with mass-spectrometric detection was developed for simultaneous quantitative determination of chlormadinone acetate and ethinyl estradiol in human blood plasma. The sample preparation method included liquid—liquid extraction using hexane—Et2O. The method was validated for selectivity, linearity, accuracy, precision, cross-transfer, and stability. The developed method enabled simultaneous determination of the chlormadinone acetate and ethinyl estradiol blood concentrations in volunteers and could be used for pharmacokinetics studies.
Негізгі сөздер
Авторлар туралы
G. Gil’deeva
Sechenov First Moscow State Medical University
Email: dsapozhnikova@mail.ru
Ресей, Moscow, 128018
A. Belostotskii
Sechenov First Moscow State Medical University
Email: dsapozhnikova@mail.ru
Ресей, Moscow, 128018
D. Sapozhnikova
MDA Ltd.
Хат алмасуға жауапты Автор.
Email: dsapozhnikova@mail.ru
Ресей, Moscow