Analysis of Sigma-1 Receptor Binding Ability Under Emotional Stress and Upon Administration of the Anxiolytic Afobazole
- Autores: Abramova E.1, Voronin M.1, Seredenin S.1
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Afiliações:
- V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- Edição: Volume 53, Nº 8 (2019)
- Páginas: 673-677
- Seção: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/245940
- DOI: https://doi.org/10.1007/s11094-019-02060-6
- ID: 245940
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Resumo
Specific binding of the sigma-1 receptor (Sigma1R) ligand [3H]-(+)-pentazocine was determined in the P2 and P3 fractions of brain homogenates from inbred BALB/c and C57BL/6 mice after emotional stress in the open-field (OF) test and outbred CD-1 mice after administration of the anxiolytic afobazole. Exposure in the OF test increased specific binding of [3H]-(+)-pentazocine to the P3 fraction of BALB/c mice brain homogenates as characterized by catatonia in the OF test and did not affect ligand binding in C57BL/6 mice with active behavior in the OF test. Afobazole at a dose of 5 mg/kg increased specific binding of [3H]-(+)-pentazocine to the P2 fraction of outbred CD-1 mice brain homogenates. The results indicated that Sigma1R was involved in the formation mechanism of emotional stress responses and in afobazole pharmacodynamics.
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Sobre autores
E. Abramova
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Autor responsável pela correspondência
Email: ryaskinv@mail.ru
Rússia, 8 Baltiiskaya, Moscow, 125315
M. Voronin
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: ryaskinv@mail.ru
Rússia, 8 Baltiiskaya, Moscow, 125315
S. Seredenin
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: ryaskinv@mail.ru
Rússia, 8 Baltiiskaya, Moscow, 125315