Analysis of Sigma-1 Receptor Binding Ability Under Emotional Stress and Upon Administration of the Anxiolytic Afobazole
- Авторлар: Abramova E.1, Voronin M.1, Seredenin S.1
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Мекемелер:
- V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- Шығарылым: Том 53, № 8 (2019)
- Беттер: 673-677
- Бөлім: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
- URL: https://journals.rcsi.science/0091-150X/article/view/245940
- DOI: https://doi.org/10.1007/s11094-019-02060-6
- ID: 245940
Дәйексөз келтіру
Аннотация
Specific binding of the sigma-1 receptor (Sigma1R) ligand [3H]-(+)-pentazocine was determined in the P2 and P3 fractions of brain homogenates from inbred BALB/c and C57BL/6 mice after emotional stress in the open-field (OF) test and outbred CD-1 mice after administration of the anxiolytic afobazole. Exposure in the OF test increased specific binding of [3H]-(+)-pentazocine to the P3 fraction of BALB/c mice brain homogenates as characterized by catatonia in the OF test and did not affect ligand binding in C57BL/6 mice with active behavior in the OF test. Afobazole at a dose of 5 mg/kg increased specific binding of [3H]-(+)-pentazocine to the P2 fraction of outbred CD-1 mice brain homogenates. The results indicated that Sigma1R was involved in the formation mechanism of emotional stress responses and in afobazole pharmacodynamics.
Негізгі сөздер
Авторлар туралы
E. Abramova
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Хат алмасуға жауапты Автор.
Email: ryaskinv@mail.ru
Ресей, 8 Baltiiskaya, Moscow, 125315
M. Voronin
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: ryaskinv@mail.ru
Ресей, 8 Baltiiskaya, Moscow, 125315
S. Seredenin
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: ryaskinv@mail.ru
Ресей, 8 Baltiiskaya, Moscow, 125315