Enviar artigo por via de e-mail Synthesis and Antiradical and Hemorheological Activity of Compounds Based on 2,6-Diisobornyl-4-Methylphenol and Polysaccharides
- Autores: Plotnikov M.1, Aliev O.1, Sidekhmenova A.1, Popova E.1, Ostrikova O.1, Kuchin A.2, Chukicheva I.2, Torlopov M.2
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Afiliações:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
- Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences
- Edição: Volume 51, Nº 10 (2018)
- Páginas: 863-866
- Seção: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244832
- DOI: https://doi.org/10.1007/s11094-018-1705-9
- ID: 244832
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Resumo
Antiradical and hemorheological activities of conjugates synthesized from 2,6-diisobornyl-4-methylphenol (dibornol) and polysaccharides [inulin, carboxymethylcellulose, hydroxyethyl starch (HES)] were studied in vitro. The dibornol—HES polymer conjugate exhibited the greatest antiradical activity of the tested compounds for the water-soluble stable radical ABTS•+ and limited statistically significantly the blood viscosity increase in an in vitro blood hyperviscosity model at a final concentration of 10–5 g/ml of blood.
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Sobre autores
M. Plotnikov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Autor responsável pela correspondência
Email: mbp2001@mail.ru
Rússia, 3 Prosp. Lenina, Tomsk, 634028
O. Aliev
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Email: mbp2001@mail.ru
Rússia, 3 Prosp. Lenina, Tomsk, 634028
A. Sidekhmenova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Email: mbp2001@mail.ru
Rússia, 3 Prosp. Lenina, Tomsk, 634028
E. Popova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Email: mbp2001@mail.ru
Rússia, 3 Prosp. Lenina, Tomsk, 634028
O. Ostrikova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk NRMC, Siberian Branch, Russian Academy of Medical Sciences
Email: mbp2001@mail.ru
Rússia, 3 Prosp. Lenina, Tomsk, 634028
A. Kuchin
Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, 48 Pervomaiskaya St., Syktyvkar, Komi Republic, 167982
I. Chukicheva
Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, 48 Pervomaiskaya St., Syktyvkar, Komi Republic, 167982
M. Torlopov
Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences
Email: mbp2001@mail.ru
Rússia, 48 Pervomaiskaya St., Syktyvkar, Komi Republic, 167982
