Preparation and Antiproliferative Activity of Glucose – Acetylsalicylic Acid Conjugate

Resumo

In this work, acetylsalicylic acid was used as the lead compound and its structure was modified by glycosylation. Glucose-based acetylsalicylic acid conjugate was prepared by using α-D-glucopyranosyl bromide as glycosyl donor and acetylsalicylic acid as acceptor. The proposed experimental procedure is simple and reproducible, providing a high yield and having great practical value. It is shown by MTT method that the glycosylated acetylsalicylic acid can inhibit in dose-dependent manner the proliferation of cancer cells.