Preparation and Antiproliferative Activity of Glucose – Acetylsalicylic Acid Conjugate
- Authors: Huang G.1, Gao H.1, Yi C.1, Ai Y.1, Huang D.1
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Affiliations:
- College of Chemistry, Chongqing Normal University
- Issue: Vol 51, No 2 (2017)
- Pages: 111-114
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244513
- DOI: https://doi.org/10.1007/s11094-017-1566-7
- ID: 244513
Cite item
Abstract
In this work, acetylsalicylic acid was used as the lead compound and its structure was modified by glycosylation. Glucose-based acetylsalicylic acid conjugate was prepared by using α-D-glucopyranosyl bromide as glycosyl donor and acetylsalicylic acid as acceptor. The proposed experimental procedure is simple and reproducible, providing a high yield and having great practical value. It is shown by MTT method that the glycosylated acetylsalicylic acid can inhibit in dose-dependent manner the proliferation of cancer cells.
About the authors
Gangliang Huang
College of Chemistry, Chongqing Normal University
Author for correspondence.
Email: huangdoctor226@163.com
China, Chongqing, 401331
Hui Gao
College of Chemistry, Chongqing Normal University
Email: huangdoctor226@163.com
China, Chongqing, 401331
Chengkun Yi
College of Chemistry, Chongqing Normal University
Email: huangdoctor226@163.com
China, Chongqing, 401331
Yanqiu Ai
College of Chemistry, Chongqing Normal University
Email: huangdoctor226@163.com
China, Chongqing, 401331
Dan Huang
College of Chemistry, Chongqing Normal University
Email: huangdoctor226@163.com
China, Chongqing, 401331