A Stability-Indicating LC-MS Method for Determination of Perindopril and its Process Related Impurities
- Авторлар: Kumar N.1, Sreenivasulu V.2, Ramachandra B.3, Asif M.1, Ibrahim A.1
-
Мекемелер:
- Department of Chemical Engineering, King Saud University
- Analytical Development Laboratory, Cipla Limited, Virgonagar
- Department of Chemistry, Government College for Men (A)
- Шығарылым: Том 52, № 4 (2018)
- Беттер: 378-383
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245197
- DOI: https://doi.org/10.1007/s11094-018-1825-2
- ID: 245197
Дәйексөз келтіру
Аннотация
Perindopril erbumine belongs to the member of angiotensin-converting enzyme inhibitors group used in the treatment of heart failure and hypertension. Asimple and highly sensitive LC-MS method has been developed for the simultaneous determination of three process-related impurities (L-norvaline, L-norvaline ethyl ester HCl, and (S)-indoline-2-carboxylic acid) in perindopril. Samples were separated using 5 mM ammonium formate (A) and acetonitrile/methanol (B) as the mobile phase on a Symmetry C18 column (75 mm × 4.6 mm, 3.5 μm) using gradient elution mode at a flow rate of 0.6 mL/min. The proposed method was validated as per ICH guidelines and can be used for quality testing of perindopril and determining its process-related impurities in pharmaceuticals.
Негізгі сөздер
Авторлар туралы
Nadavala Kumar
Department of Chemical Engineering, King Saud University
Хат алмасуға жауапты Автор.
Email: shivanadavala@gmail.com
Сауд Арабиясы, Riyadh, 11421
Vudagandla Sreenivasulu
Analytical Development Laboratory, Cipla Limited, Virgonagar
Email: shivanadavala@gmail.com
Үндістан, (Karnataka), Bangalore
Bondigalla Ramachandra
Department of Chemistry, Government College for Men (A)
Email: shivanadavala@gmail.com
Үндістан, Kadapa, Andhra Pradesh, 516004
Mohammad Asif
Department of Chemical Engineering, King Saud University
Email: shivanadavala@gmail.com
Сауд Арабиясы, Riyadh, 11421
Ahmed Ibrahim
Department of Chemical Engineering, King Saud University
Email: shivanadavala@gmail.com
Сауд Арабиясы, Riyadh, 11421