Preparation of Low-Molecular-Weight Heparins by Radiation-Induced Destruction
- Авторлар: Tuaeva N.1,2, Trukhan V.1, Kardonskii D.1, Eganov A.1, Grebenkina E.1, Veselov V.1
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Мекемелер:
- I. M. Sechenov First Moscow State Medical University
- Kazan State Medical Academy, Branch of the Russian Medical Academy for Continuing Professional Education, Ministry of Health of the Russian Federation
- Шығарылым: Том 52, № 2 (2018)
- Беттер: 122-126
- Бөлім: Drug Synthesis Methods and Manufacturing Technology
- URL: https://journals.rcsi.science/0091-150X/article/view/245023
- DOI: https://doi.org/10.1007/s11094-018-1776-7
- ID: 245023
Дәйексөз келтіру
Аннотация
Low-molecular-weight heparins (LMWHs) are widely used in medical practice. LMWHs are produced using various methods of controlled depolymerization of unfractionated heparin (UFH). Herein, a method for radiation-induced destruction of aqueous heparin solutions using a 60Co gamma-irradiation source is presented. The optimal conditions for depolymerization of starting heparin were found. The anticoagulant activity of LMWHs was studied as a function of irradiation dose. The results allowed this LMWH production method to be recommended for development of new anticoagulants.
Авторлар туралы
N. Tuaeva
I. M. Sechenov First Moscow State Medical University; Kazan State Medical Academy, Branch of the Russian Medical Academy for Continuing Professional Education, Ministry of Health of the Russian Federation
Хат алмасуға жауапты Автор.
Email: chemtox@mail.ru
Ресей, Moscow, 119991; Kazan, Tatarstan, 420012
V. Trukhan
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Ресей, Moscow, 119991
D. Kardonskii
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Ресей, Moscow, 119991
A. Eganov
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Ресей, Moscow, 119991
E. Grebenkina
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Ресей, Moscow, 119991
V. Veselov
I. M. Sechenov First Moscow State Medical University
Email: chemtox@mail.ru
Ресей, Moscow, 119991