Preparation of Low-Molecular-Weight Heparins by Radiation-Induced Destruction

N. O. Tuaeva; V. M. Trukhan; D. A. Kardonskii; A. A. Eganov; E. V. Grebenkina; V. V. Veselov

doi:10.1007/s11094-018-1776-7

Preparation of Low-Molecular-Weight Heparins by Radiation-Induced Destruction

Authors: Tuaeva N.O.¹^,2, Trukhan V.M.¹, Kardonskii D.A.¹, Eganov A.A.¹, Grebenkina E.V.¹, Veselov V.V.¹
Affiliations:
1. I. M. Sechenov First Moscow State Medical University
2. Kazan State Medical Academy, Branch of the Russian Medical Academy for Continuing Professional Education, Ministry of Health of the Russian Federation
Issue: Vol 52, No 2 (2018)
Pages: 122-126
Section: Drug Synthesis Methods and Manufacturing Technology
URL: https://journals.rcsi.science/0091-150X/article/view/245023
DOI: https://doi.org/10.1007/s11094-018-1776-7
ID: 245023

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Abstract
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Abstract

Low-molecular-weight heparins (LMWHs) are widely used in medical practice. LMWHs are produced using various methods of controlled depolymerization of unfractionated heparin (UFH). Herein, a method for radiation-induced destruction of aqueous heparin solutions using a ⁶⁰Co gamma-irradiation source is presented. The optimal conditions for depolymerization of starting heparin were found. The anticoagulant activity of LMWHs was studied as a function of irradiation dose. The results allowed this LMWH production method to be recommended for development of new anticoagulants.

Keywords

low-molecular-weight heparins, radiation-induced destruction, anticoagulant activity

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Preparation of Low-Molecular-Weight Heparins by Radiation-Induced Destruction

Full Text

Abstract

Keywords

About the authors

N. O. Tuaeva

V. M. Trukhan

D. A. Kardonskii

A. A. Eganov

E. V. Grebenkina

V. V. Veselov

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