Influence of Human Biorhythms on the Blood Glucose Level and the Efficacy of Hypoglycemic Drugs (Review)
- Authors: Bunyatyan N.D.1,2, Bukhtiyarova I.P.3, Drogovoz S.M.3, Kononenko A.V.3, Olefir Y.V.1,2, Prokof’ev A.B.1,2, Proskurina I.A.2, Goryachev D.V.2
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Affiliations:
- Sechenov First Moscow State Medical University
- Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
- National University of Pharmacy
- Issue: Vol 51, No 5 (2017)
- Pages: 399-401
- Section: Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244625
- DOI: https://doi.org/10.1007/s11094-017-1621-4
- ID: 244625
Cite item
Abstract
Rational drug use considers the medical, biological, and pharmaceutical factors that ensure high bioavailability and efficacy. On the other hand, the interaction of a drug with in vivo systems is of interest to take into account chronopharmacology, which studies drug action as a function of human biorhythms. According to chronopathology, various pathological processes and disorders, in particular diabetes mellitus (DM), are related to biorhythm disruption. The pathogenesis of DM involves desynchronosis related to not only the disruption of endogenous insulin secretion but also the artificially induced rhythm of conventional insulin therapy. Available data on the influence of carbohydrate metabolism biorhythms on the efficacy of hypoglycemic treatment were summarized. The expediency of studying and developing schedules for administered hypoglycemic drugs was discussed.
About the authors
N. D. Bunyatyan
Sechenov First Moscow State Medical University; Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 119991; Moscow, 127051
I. P. Bukhtiyarova
National University of Pharmacy
Email: chem@folium.ru
Ukraine, Kharkiv, 61000
S. M. Drogovoz
National University of Pharmacy
Email: chem@folium.ru
Ukraine, Kharkiv, 61000
A. V. Kononenko
National University of Pharmacy
Email: chem@folium.ru
Ukraine, Kharkiv, 61000
Yu. V. Olefir
Sechenov First Moscow State Medical University; Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 119991; Moscow, 127051
A. B. Prokof’ev
Sechenov First Moscow State Medical University; Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 119991; Moscow, 127051
I. A. Proskurina
Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 127051
D. V. Goryachev
Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Public Health of the Russian Federation
Email: chem@folium.ru
Russian Federation, Moscow, 127051