Assessment of the Wound-Healing Action of Spiroconjugated 1,2,3-Triazolo[5,1-b]-1,3,4-Thiadiazine in a Linear Skin Wound Model
- Authors: Vysokova O.A.1, Zhdanova A.V.1, Petrova I.M.1, Medvedeva S.Y.1, Kalinina T.A.1, Khatsko S.L.1, Kolesnikova T.O.1, Glukhareva T.V.1, Morzherin Y.Y.1
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Affiliations:
- First President of Russia B. N. Yeltsin Urals Federal University
- Issue: Vol 53, No 7 (2019)
- Pages: 642-645
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245914
- DOI: https://doi.org/10.1007/s11094-019-02054-4
- ID: 245914
Cite item
Abstract
The effects of the 5′-(4-ethoxybenzoyl)-5′,7′-dihydrospiro[cyclopentane-1,6′-[1,2,3]-triazolo[5,1-b][1,3,4]-thiadiazine]-3′-carboxylic acid ethyl ester oon the healing of linear skin wounds were studied in rats. This compound was found to have a stimulatory action on skin fibroblast proliferation, increasing the regenerative potential of damaged tissue. Assessment of the course of the wound process showed that use of test substance clearly accelerated the course of repair regeneration of the integument as compared with controls; inflammatory processes were moderate, without involvement of the deep layers of the skin; a cellular and fibrous component formed in the lesion zone.
About the authors
O. A. Vysokova
First President of Russia B. N. Yeltsin Urals Federal University
Email: t.v.glukhareva@urfu.ru
Russian Federation, 19 Mir Street, Yekaterinburg, 620002
A. V. Zhdanova
First President of Russia B. N. Yeltsin Urals Federal University
Email: t.v.glukhareva@urfu.ru
Russian Federation, 19 Mir Street, Yekaterinburg, 620002
I. M. Petrova
First President of Russia B. N. Yeltsin Urals Federal University
Email: t.v.glukhareva@urfu.ru
Russian Federation, 19 Mir Street, Yekaterinburg, 620002
S. Yu. Medvedeva
First President of Russia B. N. Yeltsin Urals Federal University
Email: t.v.glukhareva@urfu.ru
Russian Federation, 19 Mir Street, Yekaterinburg, 620002
T. A. Kalinina
First President of Russia B. N. Yeltsin Urals Federal University
Email: t.v.glukhareva@urfu.ru
Russian Federation, 19 Mir Street, Yekaterinburg, 620002
S. L. Khatsko
First President of Russia B. N. Yeltsin Urals Federal University
Email: t.v.glukhareva@urfu.ru
Russian Federation, 19 Mir Street, Yekaterinburg, 620002
T. O. Kolesnikova
First President of Russia B. N. Yeltsin Urals Federal University
Email: t.v.glukhareva@urfu.ru
Russian Federation, 19 Mir Street, Yekaterinburg, 620002
T. V. Glukhareva
First President of Russia B. N. Yeltsin Urals Federal University
Author for correspondence.
Email: t.v.glukhareva@urfu.ru
Russian Federation, 19 Mir Street, Yekaterinburg, 620002
Yu. Yu. Morzherin
First President of Russia B. N. Yeltsin Urals Federal University
Email: t.v.glukhareva@urfu.ru
Russian Federation, 19 Mir Street, Yekaterinburg, 620002