Development of Light-Protective Gels Containing Xymedone and Amphiphilic Components

Abstract

Arelevant task in the technology of cosmetic and pharmaceutical substances is that of protecting the skin from the harmful influences of ultraviolet light - sunburn, photodermatoses, skin cancerogenesis, and light-induced aging. Gels containing N-(β-hydroxyethyl)-4,6-dimethyldihydropyrimidone-2 (xymedone) and amphiphilic components, i.e., nonionic surface-active substances (surfactants), were developed and studied. Aspectrophotometric method was used to study the selective absorption of xymedone in the UV range. Overall, the structural- mechanical characteristics of gels and assessment of the effects of surfactant on xymedone release processes were used to select the optimum composition for effective protection against light by gels. Studies in models of ultraviolet erythema in albino guinea pigs and volunteers receiving prophylactic applications showed that xymedone-containing gel had photoprotective effects. The presence of a hydroxyethylated higher fatty alcohol in the gel composition with xymedone increased its photoprotective activity.