Evaluation of the Antioxidant, Hepatoprotective, and Anti-Inflammatory Activities of Bisresorcinol Isolated from the Trunk of Heliciopsis Terminalis
- Authors: Giang P.M.1, Thao D.T.2,3, Nga N.T.2, Van Trung B.4, Anh D.H.5, Viet P.H.5
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Affiliations:
- Faculty of Chemistry, VNU University of Science, Vietnam National University
- Institute of Biotechnology, Vietnam Academy of Science and Technology
- Graduate University of Science and Technology, Vietnam Academy of Science and Technology
- National Institute for Drug Quality Control, Ministry of Health
- Research Centre for Environmental Technology and Sustainable Development, VNU University of Science, Vietnam National University
- Issue: Vol 53, No 7 (2019)
- Pages: 628-634
- Section: Medicinal Plants
- URL: https://journals.rcsi.science/0091-150X/article/view/245908
- DOI: https://doi.org/10.1007/s11094-019-02051-7
- ID: 245908
Cite item
Abstract
A bisresorcinol, (8′Z)-3,5-dihydroxy-1-[16′-(3″,5″-dihydroxyphenyl)-8′-hexadecen-1′-yl]benzene (I), was isolated as an abundant constituent from the Vietnamese medicinal plant Heliciopsis terminalis (Kurz) Sleumer (Proteaceae). The antioxidant, hepatoprotective, and anti-inflammatory activities of compound I were tested in correlation with the use of H. terminalis as a hepatoprotective drug by ethnic people in Vietnam. Bisresorcinol I showed weak scavenging activity against DPPH radical at an EC50 value of 156.9 mg/mL. At a concentration of 100 mg/mL, compound I inhibited 19,78% of MDAproduction as one of the biomarkers for lipid peroxidation. Bisresorcinol I protected HepG2 cells against harmful CCl4. The hepatoprotective ability was observed at a concentration of 100 mg/mL with up to 44.42% cells alive, which was significantly higher than that in the control treated with CCl4 (29.93 %). The NO scavenging activity of I was determined in RAW 264.7 cells with an IC50 value of 71.15 mg/mL. Bisresorcinol I exhibited its anti-inflammatory activity through modulation of proinflammatory cytokines IL-6 and TNF-α as well as anti-inflammatory IL-10 in RAW264.7 cells.
About the authors
Phan Minh Giang
Faculty of Chemistry, VNU University of Science, Vietnam National University
Author for correspondence.
Email: phanminhgiang@yahoo.com
Viet Nam, Hanoi, 19 Le Thanh Tong Street, Hanoi
Do Thi Thao
Institute of Biotechnology, Vietnam Academy of Science and Technology; Graduate University of Science and Technology, Vietnam Academy of Science and Technology
Email: phanminhgiang@yahoo.com
Viet Nam, 18 Hoang Quoc Viet Street, Nghia Do, Cau Giay, Hanoi; 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi
Nguyen Thi Nga
Institute of Biotechnology, Vietnam Academy of Science and Technology
Email: phanminhgiang@yahoo.com
Viet Nam, 18 Hoang Quoc Viet Street, Nghia Do, Cau Giay, Hanoi
Bui Van Trung
National Institute for Drug Quality Control, Ministry of Health
Email: phanminhgiang@yahoo.com
Viet Nam, 48 Hai Ba Trung Street, Hanoi
Duong Hong Anh
Research Centre for Environmental Technology and Sustainable Development, VNU University of Science, Vietnam National University
Email: phanminhgiang@yahoo.com
Viet Nam, Hanoi, 334 Nguyen Trai Street, Hanoi
Pham Hung Viet
Research Centre for Environmental Technology and Sustainable Development, VNU University of Science, Vietnam National University
Email: phanminhgiang@yahoo.com
Viet Nam, Hanoi, 334 Nguyen Trai Street, Hanoi