Synthesis and  In Vivo  Evaluation of New Coumarin Conjugates as Potential Indirect-Action Anticoagulants

Nguyen Cong Bang; A. Z. Abyshev; D. Yu. Ivkin

doi:10.1007/s11094-019-02013-z

Synthesis and In Vivo Evaluation of New Coumarin Conjugates as Potential Indirect-Action Anticoagulants

作者: Bang N.C.¹, Abyshev A.Z.¹, Ivkin D.Y.¹
隶属关系:
1. St. Petersburg State Chemical Pharmaceutical University
期: 卷 53, 编号 5 (2019)
页面: 419-422
栏目: Search for New Drugs
URL: https://journals.rcsi.science/0091-150X/article/view/245792
DOI: https://doi.org/10.1007/s11094-019-02013-z
ID: 245792

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A synthetic method for a series of new coumarin conjugates was developed. Their structures and physicochemical properties were determined by modern spectral methods (IR, NMR, ESI-MS). The anticoagulant activity was studied in vivo by determining the prothrombin time (PT). Compounds 4a (PT = 10.88 ± 0.56 sec) and 4b (13.10 ± 3.56 sec) were the most active and comparable to the reference drug warfarin (7.97 ± 1.93 sec).