Email this article Synthesis and In Vivo Evaluation of New Coumarin Conjugates as Potential Indirect-Action Anticoagulants
- Authors: Bang N.C.1, Abyshev A.Z.1, Ivkin D.Y.1
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Affiliations:
- St. Petersburg State Chemical Pharmaceutical University
- Issue: Vol 53, No 5 (2019)
- Pages: 419-422
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/245792
- DOI: https://doi.org/10.1007/s11094-019-02013-z
- ID: 245792
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Abstract
A synthetic method for a series of new coumarin conjugates was developed. Their structures and physicochemical properties were determined by modern spectral methods (IR, NMR, ESI-MS). The anticoagulant activity was studied in vivo by determining the prothrombin time (PT). Compounds 4a (PT = 10.88 ± 0.56 sec) and 4b (13.10 ± 3.56 sec) were the most active and comparable to the reference drug warfarin (7.97 ± 1.93 sec).
About the authors
Nguyen Cong Bang
St. Petersburg State Chemical Pharmaceutical University
Author for correspondence.
Email: nguyencongbang@mail.ru
Russian Federation, St. Petersburg, 197376
A. Z. Abyshev
St. Petersburg State Chemical Pharmaceutical University
Email: nguyencongbang@mail.ru
Russian Federation, St. Petersburg, 197376
D. Yu. Ivkin
St. Petersburg State Chemical Pharmaceutical University
Email: nguyencongbang@mail.ru
Russian Federation, St. Petersburg, 197376
