Hypolipidemic Action of Medicinal Plant Extracts for Experimental Diabetes Mellitus
- Authors: Vengerovskii A.I.1, Yakimova T.V.1, Nasanova O.N.1
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Affiliations:
- Siberian State Medical University, Ministry of Health of Russia
- Issue: Vol 53, No 3 (2019)
- Pages: 239-242
- Section: Medicinal Plants
- URL: https://journals.rcsi.science/0091-150X/article/view/245714
- DOI: https://doi.org/10.1007/s11094-019-01986-1
- ID: 245714
Cite item
Abstract
Aqueous extracts of nettle leaves (100 mg/kg) and greater burdock roots (25 mg/kg) decreased the blood levels of glucose, triglycerides, total cholesterol, and low- and very-low-density lipoproteins; increased the cholesterol and protein contents of high-density lipoproteins; and prevented low-density lipoprotein oxidation and high-density lipoprotein and hemoglobin glycosylation in experimental diabetes mellitus induced in rats by streptozotocin and a high-fat (30%) diet. The hypolipidemic action of the plant extracts did not decrease if the animals were fed a high-fat diet. Rosiglitazone exhibited more significant hypoglycemic and hypolipidemic effects with a low-fat diet. Flavonoids and carotenoids were responsible for the antidiabetic action of the nettle and burdock extracts.
About the authors
A. I. Vengerovskii
Siberian State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: pharm-sibgmu@rambler.ru
Russian Federation, Tomsk, 634050
T. V. Yakimova
Siberian State Medical University, Ministry of Health of Russia
Email: pharm-sibgmu@rambler.ru
Russian Federation, Tomsk, 634050
O. N. Nasanova
Siberian State Medical University, Ministry of Health of Russia
Email: pharm-sibgmu@rambler.ru
Russian Federation, Tomsk, 634050