Hypolipidemic Action of Medicinal Plant Extracts for Experimental Diabetes Mellitus
- Авторы: Vengerovskii A.1, Yakimova T.1, Nasanova O.1
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Учреждения:
- Siberian State Medical University, Ministry of Health of Russia
- Выпуск: Том 53, № 3 (2019)
- Страницы: 239-242
- Раздел: Medicinal Plants
- URL: https://journals.rcsi.science/0091-150X/article/view/245714
- DOI: https://doi.org/10.1007/s11094-019-01986-1
- ID: 245714
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Аннотация
Aqueous extracts of nettle leaves (100 mg/kg) and greater burdock roots (25 mg/kg) decreased the blood levels of glucose, triglycerides, total cholesterol, and low- and very-low-density lipoproteins; increased the cholesterol and protein contents of high-density lipoproteins; and prevented low-density lipoprotein oxidation and high-density lipoprotein and hemoglobin glycosylation in experimental diabetes mellitus induced in rats by streptozotocin and a high-fat (30%) diet. The hypolipidemic action of the plant extracts did not decrease if the animals were fed a high-fat diet. Rosiglitazone exhibited more significant hypoglycemic and hypolipidemic effects with a low-fat diet. Flavonoids and carotenoids were responsible for the antidiabetic action of the nettle and burdock extracts.
Об авторах
A. Vengerovskii
Siberian State Medical University, Ministry of Health of Russia
Автор, ответственный за переписку.
Email: pharm-sibgmu@rambler.ru
Россия, Tomsk, 634050
T. Yakimova
Siberian State Medical University, Ministry of Health of Russia
Email: pharm-sibgmu@rambler.ru
Россия, Tomsk, 634050
O. Nasanova
Siberian State Medical University, Ministry of Health of Russia
Email: pharm-sibgmu@rambler.ru
Россия, Tomsk, 634050