Synthesis and Antiviral Activity of Polycyclic N-Amidoimides Based on 4-Oxatetracyclo-[5.3.2.02, 6.08, 10]Dodec-11-Ene-3,5-Dione
- Authors: Selivanov B.A.1, Bormotov N.I.2, Shishkina L.N.2, Belanov E.F.2, Serova O.A.2, Kabanov A.S.2, Mazurkov O.Y.2, Tikhonov A.Y.1
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Affiliations:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh, SB, RAS)
- Vector State Research Center for Virology and Biotechnology
- Issue: Vol 52, No 10 (2019)
- Pages: 820-824
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/245488
- DOI: https://doi.org/10.1007/s11094-019-1907-9
- ID: 245488
Cite item
Abstract
A series of novel polycyclic N-amidoimides were synthesized by reacting 4-oxatetracyclo[5.3.2.02,6.08,10]dodec-11-ene-3,5-dione with hydrazides of benzoic acids, arylaminoacetic acid, and oxalic acid. The most pronounced antiviral activities against Vaccinia virus were observed for 4-hydroxy-N-(3,5-dioxo-4-azatetracyclo[5.3.2.02, 6.08, 10]dodec-11-en-4-yl)-3-nitrobenzamide, N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)-N′-[(3-trifluoromethyl)phenyl]ethanediamide, and N-(2,6-dimethylphenyl)-N′-(3,5-dioxo-4-azatetracyclo-5.3.2.02,6,08,10]dodec-11-en-4-yl)ethanediamide.
About the authors
B. A. Selivanov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh, SB, RAS)
Email: alyatikh@nioch.nsc.ru
Russian Federation, 9 Prosp. Akad. Lavrent’eva, Novosibirsk 90, 630090
N. I. Bormotov
Vector State Research Center for Virology and Biotechnology
Email: alyatikh@nioch.nsc.ru
Russian Federation, Kol’tsovo, Novosibirsk Oblast, 630559
L. N. Shishkina
Vector State Research Center for Virology and Biotechnology
Email: alyatikh@nioch.nsc.ru
Russian Federation, Kol’tsovo, Novosibirsk Oblast, 630559
E. F. Belanov
Vector State Research Center for Virology and Biotechnology
Email: alyatikh@nioch.nsc.ru
Russian Federation, Kol’tsovo, Novosibirsk Oblast, 630559
O. A. Serova
Vector State Research Center for Virology and Biotechnology
Email: alyatikh@nioch.nsc.ru
Russian Federation, Kol’tsovo, Novosibirsk Oblast, 630559
A. S. Kabanov
Vector State Research Center for Virology and Biotechnology
Email: alyatikh@nioch.nsc.ru
Russian Federation, Kol’tsovo, Novosibirsk Oblast, 630559
O. Yu. Mazurkov
Vector State Research Center for Virology and Biotechnology
Email: alyatikh@nioch.nsc.ru
Russian Federation, Kol’tsovo, Novosibirsk Oblast, 630559
A. Ya. Tikhonov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCh, SB, RAS)
Author for correspondence.
Email: alyatikh@nioch.nsc.ru
Russian Federation, 9 Prosp. Akad. Lavrent’eva, Novosibirsk 90, 630090