Email this article Development and Validation of a Quantitative Determination Technique for Phenibut in Microcapsules
- Authors: Polkovnikova Y.A.1, Koryanova K.N.2, Slivkin A.I.1, Tul’skaya U.A.1, Senchenko S.P.2
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Affiliations:
- Voronezh State University
- Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
- Issue: Vol 52, No 9 (2018)
- Pages: 803-807
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245477
- DOI: https://doi.org/10.1007/s11094-018-1904-4
- ID: 245477
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Abstract
A capillary electrophoresis technique for quantitative determination of phenibut in microcapsules was developed and validated. Rather high efficiencies (~200,000 theoretical plates) and the required resolution (Rs ≥ 1.5) were attained using sodium tetraborate decahydrate solution (10 mM) at pH 9.2 as the supporting electrolyte. Validation of the technique showed that it was specific and complied with requirements of the SP XIIIth Ed. with respect to analytical range and linearity.
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About the authors
Yu. A. Polkovnikova
Voronezh State University
Author for correspondence.
Email: juli-polk@mail.ru
Russian Federation, Studencheskaya St., Voronezh, 394006
K. N. Koryanova
Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
Email: juli-polk@mail.ru
Russian Federation, 11 Kalinina Prosp., Pyatigorsk, Stavropol’skii Krai, 357532
A. I. Slivkin
Voronezh State University
Email: juli-polk@mail.ru
Russian Federation, Studencheskaya St., Voronezh, 394006
U. A. Tul’skaya
Voronezh State University
Email: juli-polk@mail.ru
Russian Federation, Studencheskaya St., Voronezh, 394006
S. P. Senchenko
Pyatigorsk Medico-Pharmaceutical Institute, Branch of Volgograd State Medical University
Email: juli-polk@mail.ru
Russian Federation, 11 Kalinina Prosp., Pyatigorsk, Stavropol’skii Krai, 357532
