Synthesis and Antimicrobial, Antiprotozoal, and Fungistatic Activity of [5-(Amino-, Acylamino-, and 2-Pyridylmethylamino)-1-Alkylbenzimidazol-2-yl]Diphenylmethanols

Abstract

5-(Amino- and 2-pyridylmethylamino)-1-alkylbenzimidazoles treated sequentially with butyllithium and benzophenone synthesized [5-(amino- and 2-pyridylmethylamino)-1-alkylbenzimidazol-2-yl]diphenylmethanols. (5-Amino-1-methylbenzimidazol-2-yl)diphenylmethanol was converted by acyl chlorides into (5-acylamino-1-methylbenzimidazol-2-yl)diphenylmethanols. The products were shown to possess bacteriostatic activity against Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli), antiprotozoal activity against the ciliate Colpoda steinii, and fungicidal activity against Penicillium italicum.