Antioxidant and Antiradical Activity of Drugs Intended for Treating Ophthalmic Disorders
- Authors: Ivanova A.V.1, Gerasimova E.L.1, Gazizullina E.R.1, Okulova Y.A.1, Matern A.I.1, Rusinov V.L.1
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Affiliations:
- Institute of Chemical Technology, B. N. Yeltsin Ural Federal University
- Issue: Vol 52, No 8 (2018)
- Pages: 694-699
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245415
- DOI: https://doi.org/10.1007/s11094-018-1883-5
- ID: 245415
Cite item
Abstract
Dosage forms intended for ophthalmic use with declared and potential antioxidant properties were investigated. Antioxidant activity was determined using potentiometry with potassium hexacyanoferrate (III) as the oxidant. Antiradical activity was studied using the stable radical 2,2-diphenyl-1-picrylhydrazyl. The reaction half-lives of the investigated dosage forms were determined. Ratios of the experimental antioxidant activity to the content of main active ingredient were assessed.
About the authors
A. V. Ivanova
Institute of Chemical Technology, B. N. Yeltsin Ural Federal University
Author for correspondence.
Email: a.v.ivanova@urfu.ru
Russian Federation, 19 Mir St., Ekaterinburg, 620002
E. L. Gerasimova
Institute of Chemical Technology, B. N. Yeltsin Ural Federal University
Email: a.v.ivanova@urfu.ru
Russian Federation, 19 Mir St., Ekaterinburg, 620002
E. R. Gazizullina
Institute of Chemical Technology, B. N. Yeltsin Ural Federal University
Email: a.v.ivanova@urfu.ru
Russian Federation, 19 Mir St., Ekaterinburg, 620002
Ya. A. Okulova
Institute of Chemical Technology, B. N. Yeltsin Ural Federal University
Email: a.v.ivanova@urfu.ru
Russian Federation, 19 Mir St., Ekaterinburg, 620002
A. I. Matern
Institute of Chemical Technology, B. N. Yeltsin Ural Federal University
Email: a.v.ivanova@urfu.ru
Russian Federation, 19 Mir St., Ekaterinburg, 620002
V. L. Rusinov
Institute of Chemical Technology, B. N. Yeltsin Ural Federal University
Email: a.v.ivanova@urfu.ru
Russian Federation, 19 Mir St., Ekaterinburg, 620002