Email this article Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives
- Authors: Shivaprasad Shetty M.1, Anil Kumar H.S.2, Anil Kumar N.V.3
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Affiliations:
- Department of Chemistry, NMAM Institute of Technology
- Department of Biotechnology, NMAM Institute of Technology
- Department of Chemistry, Manipal Institute of Technology, Manipal Academy of higher Education
- Issue: Vol 52, No 6 (2018)
- Pages: 526-530
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245304
- DOI: https://doi.org/10.1007/s11094-018-1853-y
- ID: 245304
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Abstract
A series of nine molecules of coumarin hydrazone derivatives have been synthesized. The purpose of this study was to investigate the anti-diabetic activity of synthesized coumarin derivatives by inhibition of α-amylase enzyme isolated from Aspergillus niger microbial strain. The experiment was conducted by taking 5, 10, 50, and 100 μg/mL of each compound and acarbose as a positive control. The tests showed that compounds 3f (IC50 = 49.70 μg/mL), 3g (IC50 = 79.20 μg/mL), and 3i (IC50 = 48.80 μg/mL) as well as reference drug (IC50 = 81.70 μg/mL) exhibited inhibition activity against the enzyme. The synthesized compounds may be helpful in controlling the glucose level as α-amylase is one of the causes of increased sugar level in human body.
About the authors
M. Shivaprasad Shetty
Department of Chemistry, NMAM Institute of Technology
Email: nv.anil@manipal.edu
India, Nitte, Karkala, 574110
H. S. Anil Kumar
Department of Biotechnology, NMAM Institute of Technology
Email: nv.anil@manipal.edu
India, Nitte, Karkala, 574110
N. V. Anil Kumar
Department of Chemistry, Manipal Institute of Technology, Manipal Academy of higher Education
Author for correspondence.
Email: nv.anil@manipal.edu
India, Manipal, 576014
