Synthesis and α-Amylase Inhibition Studies of Some Coumarin Derivatives

Resumo

A series of nine molecules of coumarin hydrazone derivatives have been synthesized. The purpose of this study was to investigate the anti-diabetic activity of synthesized coumarin derivatives by inhibition of α-amylase enzyme isolated from Aspergillus niger microbial strain. The experiment was conducted by taking 5, 10, 50, and 100 μg/mL of each compound and acarbose as a positive control. The tests showed that compounds 3f (IC₅₀ = 49.70 μg/mL), 3g (IC₅₀ = 79.20 μg/mL), and 3i (IC₅₀ = 48.80 μg/mL) as well as reference drug (IC₅₀ = 81.70 μg/mL) exhibited inhibition activity against the enzyme. The synthesized compounds may be helpful in controlling the glucose level as α-amylase is one of the causes of increased sugar level in human body.