Email this article Granulation of Effervescent Ingredients for Optimization of Gastroretentive Properties of Floating Proroxan Prolonged-Release Tablets
- Authors: Nifontova G.O.1,2, Krechetov S.P.1, Dolotova O.V.1, Buyukli S.R.1, Akhmetzyanova A.R.3, Krasnyuk I.I.2
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Affiliations:
- School of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University)
- I. M. Sechenov First Moscow State Medical University
- Farmzashchita Research and Production Center, Federal Medico-Biological Agency of the Russian Federation
- Issue: Vol 52, No 4 (2018)
- Pages: 361-365
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245182
- DOI: https://doi.org/10.1007/s11094-018-1822-5
- ID: 245182
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Abstract
Research results supporting the manufacturing technology for floating prolonged-release oral tablets based on a hydrophilic matrix with the nonselective α-adrenoblocker proroxan are presented.Wet granulation of the effervescent ingredients with the matrix produced tablets with the required buoyancy lag-time, float time, and proroxan release kinetics.
About the authors
G. O. Nifontova
School of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University); I. M. Sechenov First Moscow State Medical University
Author for correspondence.
Email: galya.nif@yandex.ru
Russian Federation, Dolgoprudnyi, Moscow Region, 141700; Moscow, 119991
S. P. Krechetov
School of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University)
Email: galya.nif@yandex.ru
Russian Federation, Dolgoprudnyi, Moscow Region, 141700
O. V. Dolotova
School of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University)
Email: galya.nif@yandex.ru
Russian Federation, Dolgoprudnyi, Moscow Region, 141700
S. R. Buyukli
School of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University)
Email: galya.nif@yandex.ru
Russian Federation, Dolgoprudnyi, Moscow Region, 141700
A. R. Akhmetzyanova
Farmzashchita Research and Production Center, Federal Medico-Biological Agency of the Russian Federation
Email: galya.nif@yandex.ru
Russian Federation, Khimki, Moscow Region, 141402
I. I. Krasnyuk
I. M. Sechenov First Moscow State Medical University
Email: galya.nif@yandex.ru
Russian Federation, Moscow, 119991
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