Synthesis and Antiproliferative Activity of Daunorubicin Conjugates with Sesquiterpene Lactones
- Authors: Anikina L.V.1, Semakov A.V.1, Afanas’eva S.V.1, Pukhov S.A.1, Klochkov S.G.1
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Affiliations:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Issue: Vol 52, No 4 (2018)
- Pages: 308-311
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245151
- DOI: https://doi.org/10.1007/s11094-018-1812-7
- ID: 245151
Cite item
Abstract
The anthracycline antibiotic daunorubicin was modified by alantolactone, isoalantolactone, and alloahntolactone, i.e., sesquitapene lactones from Inula helenium L. The antiproliferative properties of the synthesized conjugates were studied using tumor and normal cell lines. It was found that the conjugate of daunorubicin with alantolactone possessed more pronounced antiproliferative properties than daunorubicin for several tumor cell cultures without increasing the toxicity for normal cells.
About the authors
L. V. Anikina
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: klochkov@ipac.ac.ru
Russian Federation, 1 Severnyi Proezd, Chernogolovka, Moscow Oblast, 142432
A. V. Semakov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: klochkov@ipac.ac.ru
Russian Federation, 1 Severnyi Proezd, Chernogolovka, Moscow Oblast, 142432
S. V. Afanas’eva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: klochkov@ipac.ac.ru
Russian Federation, 1 Severnyi Proezd, Chernogolovka, Moscow Oblast, 142432
S. A. Pukhov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: klochkov@ipac.ac.ru
Russian Federation, 1 Severnyi Proezd, Chernogolovka, Moscow Oblast, 142432
S. G. Klochkov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Author for correspondence.
Email: klochkov@ipac.ac.ru
Russian Federation, 1 Severnyi Proezd, Chernogolovka, Moscow Oblast, 142432