Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin

I. I. Krasnyuk; T. M. Kosheleva; A. V. Belyatskaya; I. I. Krasnyuk; O. I. Stepanova; Yu. Skovpen; V. V. Grikh; L. V. Ovsyannikova

doi:10.1007/s11094-018-1799-0

Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin

Authors: Krasnyuk I.I.¹, Kosheleva T.M.¹, Belyatskaya A.V.¹, Krasnyuk I.I.¹, Stepanova O.I.¹, Skovpen Y.², Grikh V.V.¹, Ovsyannikova L.V.¹
Affiliations:
1. I. M. Sechenov First Moscow State Medical University
2. Rancho BioSciences
Issue: Vol 52, No 3 (2018)
Pages: 241-244
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/245101
DOI: https://doi.org/10.1007/s11094-018-1799-0
ID: 245101

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Abstract

Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H₂O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions.

Keywords

indomethacin, solid dispersions, polyethylene glycol 1500, solubility, crystallinity

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Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin

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Abstract

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About the authors

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