Effect of Solid Dispersions with Polyethylene Glycol 1500 on the Solubility of Indomethacin
- Авторлар: Krasnyuk I.1, Kosheleva T.1, Belyatskaya A.1, Krasnyuk I.1, Stepanova O.1, Skovpen Y.2, Grikh V.1, Ovsyannikova L.1
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Мекемелер:
- I. M. Sechenov First Moscow State Medical University
- Rancho BioSciences
- Шығарылым: Том 52, № 3 (2018)
- Беттер: 241-244
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/245101
- DOI: https://doi.org/10.1007/s11094-018-1799-0
- ID: 245101
Дәйексөз келтіру
Аннотация
Solid dispersions (SDs) of indomethacin with polyethylene glycol 1500 (PEG-1500) were studied to determine their effect on indomethacin solubility. Production of SDs increased the solubility and dissolution rate of indomethacin in H2O. The solubility and dissolution rate of indomethacin from SDs increased by 1.8 – 2.2 and 3.1 – 4.4 times, respectively. Indomethacin became less crystalline and then amorphous during preparation of the SDs. Dissolution of the SDs solubilized indomethacin and formed colloidal solutions.
Негізгі сөздер
Авторлар туралы
I. Krasnyuk
I. M. Sechenov First Moscow State Medical University
Email: krasnyuk.79@mail.ru
Ресей, 8/2 Trubetskaya St., Moscow, 119991
T. Kosheleva
I. M. Sechenov First Moscow State Medical University
Email: krasnyuk.79@mail.ru
Ресей, 8/2 Trubetskaya St., Moscow, 119991
A. Belyatskaya
I. M. Sechenov First Moscow State Medical University
Email: krasnyuk.79@mail.ru
Ресей, 8/2 Trubetskaya St., Moscow, 119991
I. Krasnyuk
I. M. Sechenov First Moscow State Medical University
Хат алмасуға жауапты Автор.
Email: krasnyuk.79@mail.ru
Ресей, 8/2 Trubetskaya St., Moscow, 119991
O. Stepanova
I. M. Sechenov First Moscow State Medical University
Email: krasnyuk.79@mail.ru
Ресей, 8/2 Trubetskaya St., Moscow, 119991
Yu. Skovpen
Rancho BioSciences
Email: krasnyuk.79@mail.ru
АҚШ, 16955 Via Del Campo Suite 220, San Diego, CA, 92127
V. Grikh
I. M. Sechenov First Moscow State Medical University
Email: krasnyuk.79@mail.ru
Ресей, 8/2 Trubetskaya St., Moscow, 119991
L. Ovsyannikova
I. M. Sechenov First Moscow State Medical University
Email: krasnyuk.79@mail.ru
Ресей, 8/2 Trubetskaya St., Moscow, 119991