Acetoxybenzoylglycylglycines as Potential Cerebroprotective Compounds


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Abstract

3,4,5-Trimethoxy- and 2-, 3-, and 4-acetoxybenzoylglycylglycines and their water-soluble potassium and lithium salts were synthesized. The cerebroprotective properties of the water-soluble potassium and lithium salts of acetoxybenzoylglycylglycines were studied experimentally. The most marked cerebroprotective proteins in cerebral ischemia were found with the lithium salt of 2-acetoxybenzoylglycylglycine.

About the authors

A. K. Brel’

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, 1 Pavshikh Bortsov Square, Volgograd, 400131

I. N. Tyurenkov

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, 1 Pavshikh Bortsov Square, Volgograd, 400131

S. V. Lisina

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, 1 Pavshikh Bortsov Square, Volgograd, 400131

S. S. Popov

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, 1 Pavshikh Bortsov Square, Volgograd, 400131

D. V. Verkholyak

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, 1 Pavshikh Bortsov Square, Volgograd, 400131

Yu. N. Budaeva

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, 1 Pavshikh Bortsov Square, Volgograd, 400131

E. V. Volotova

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, 1 Pavshikh Bortsov Square, Volgograd, 400131

N. V. Atapina

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, 1 Pavshikh Bortsov Square, Volgograd, 400131

D. V. Kurkin

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: chem@folium.ru
Russian Federation, 1 Pavshikh Bortsov Square, Volgograd, 400131


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