Acetoxybenzoylglycylglycines as Potential Cerebroprotective Compounds

A. K. Brel’; I. N. Tyurenkov; S. V. Lisina; S. S. Popov; D. V. Verkholyak; Yu. N. Budaeva; E. V. Volotova; N. V. Atapina; D. V. Kurkin

doi:10.1007/s11094-018-1762-0

Acetoxybenzoylglycylglycines as Potential Cerebroprotective Compounds

Autores: Brel’ A.¹, Tyurenkov I.¹, Lisina S.¹, Popov S.¹, Verkholyak D.¹, Budaeva Y.¹, Volotova E.¹, Atapina N.¹, Kurkin D.¹
Afiliações:
1. Volgograd State Medical University, Ministry of Health of the Russian Federation
Edição: Volume 52, Nº 1 (2018)
Páginas: 37-41
Seção: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244980
DOI: https://doi.org/10.1007/s11094-018-1762-0
ID: 244980

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Resumo

3,4,5-Trimethoxy- and 2-, 3-, and 4-acetoxybenzoylglycylglycines and their water-soluble potassium and lithium salts were synthesized. The cerebroprotective properties of the water-soluble potassium and lithium salts of acetoxybenzoylglycylglycines were studied experimentally. The most marked cerebroprotective proteins in cerebral ischemia were found with the lithium salt of 2-acetoxybenzoylglycylglycine.

Palavras-chave

carbonic acid amides, hydroxybenzoic acid derivatives, cerebroprotective agents, synthesis