Email this article Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma
- Authors: Sokolova A.S.1,2, Yarovaya O.I.1,2, Nefedov A.A.1,2, Salakhutdinov N.F.1,2
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Affiliations:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
- Novosibirsk State University
- Issue: Vol 51, No 12 (2018)
- Pages: 1102-1105
- Section: Structure of Chemical Compounds, Methods of Analysis and Process Control
- URL: https://journals.rcsi.science/0091-150X/article/view/244929
- DOI: https://doi.org/10.1007/s11094-018-1748-y
- ID: 244929
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Abstract
A new GC-MS method for determining an antiviral agent (camphecin) in blood plasma was developed. Sample preparation consisted of precipitating proteins using MeOH. The method was validated for selectivity, calibration curve, accuracy, precision, limit of quantitation, carryover, and stability. The analytical range was 0.1 – 2 μg/mL. The method could be used for pharmacokinetic studies.
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About the authors
A. S. Sokolova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Author for correspondence.
Email: a.s.sokolova@mail.ru
Russian Federation, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
O. I. Yarovaya
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: a.s.sokolova@mail.ru
Russian Federation, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
A. A. Nefedov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: a.s.sokolova@mail.ru
Russian Federation, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
N. F. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: a.s.sokolova@mail.ru
Russian Federation, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
