Отправить статью по E-mail Development and Validation of a Method for Determination of a New Effective Inhibitor of Influenza Virus H1N1 in Blood Plasma
- Авторы: Sokolova A.S.1,2, Yarovaya O.I.1,2, Nefedov A.A.1,2, Salakhutdinov N.F.1,2
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Учреждения:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
- Novosibirsk State University
- Выпуск: Том 51, № 12 (2018)
- Страницы: 1102-1105
- Раздел: Structure of Chemical Compounds, Methods of Analysis and Process Control
- URL: https://journals.rcsi.science/0091-150X/article/view/244929
- DOI: https://doi.org/10.1007/s11094-018-1748-y
- ID: 244929
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Аннотация
A new GC-MS method for determining an antiviral agent (camphecin) in blood plasma was developed. Sample preparation consisted of precipitating proteins using MeOH. The method was validated for selectivity, calibration curve, accuracy, precision, limit of quantitation, carryover, and stability. The analytical range was 0.1 – 2 μg/mL. The method could be used for pharmacokinetic studies.
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Об авторах
A. Sokolova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Автор, ответственный за переписку.
Email: a.s.sokolova@mail.ru
Россия, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
O. Yarovaya
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: a.s.sokolova@mail.ru
Россия, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
A. Nefedov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: a.s.sokolova@mail.ru
Россия, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
N. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State University
Email: a.s.sokolova@mail.ru
Россия, 9 Pr. Akad. Lavrent’eva, Novosibirsk, 630090; 2 Pirogova St., Novosibirsk, 630090
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