Email this article Synthesis and Antidepressant Properties of 3-Methyl-7-(1,1-Dioxothietan-3-YL)-8-Cyclohexylamino-1-Ethyl-1H-Purine-2,6(3H,7H)-Dione
- Authors: Khaliullin F.A.1, Shabalina Y.V.1, Davlyatova G.G.1, Valeeva L.A.1
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Affiliations:
- Bashkir State Medical University, Ministry of Health of the RF, Ufa
- Issue: Vol 51, No 12 (2018)
- Pages: 1049-1052
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244908
- DOI: https://doi.org/10.1007/s11094-018-1738-0
- ID: 244908
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Abstract
3-Methyl-7-(1,1-dioxothietan-3-yl)-8-cyclohexylamino-1-ethyl-1H-purine-2,6(3H,7H)-dione was synthesized via the reaction of 8-bromo-3-methyl-7-(1,1-dioxothietan-3-yl)-1-ethyl-1H-purine-2,6(3H,7H)-dione and cyclohexylamine and exhibited antidepressant activity that was most pronounced at a dose of 1.6 mg/kg.
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About the authors
F. A. Khaliullin
Bashkir State Medical University, Ministry of Health of the RF, Ufa
Email: chem@folium.ru
Russian Federation, Bashkortostan, 450008
Yu. V. Shabalina
Bashkir State Medical University, Ministry of Health of the RF, Ufa
Email: chem@folium.ru
Russian Federation, Bashkortostan, 450008
G. G. Davlyatova
Bashkir State Medical University, Ministry of Health of the RF, Ufa
Email: chem@folium.ru
Russian Federation, Bashkortostan, 450008
L. A. Valeeva
Bashkir State Medical University, Ministry of Health of the RF, Ufa
Email: chem@folium.ru
Russian Federation, Bashkortostan, 450008
