Synthesis and Antiproliferative Activity Evaluation of Aryl(Hetaryl)Cyclopentenone Analogs of Combretastatin A-4
- Authors: Shirinyan V.Z.1, Markosyan A.I.2, Baryshnikova M.A.3, Yaminova L.V.4, L’vov A.G.1, Gabrielyan S.A.2
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Affiliations:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
- N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- Issue: Vol 51, No 10 (2018)
- Pages: 867-872
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244834
- DOI: https://doi.org/10.1007/s11094-018-1706-8
- ID: 244834
Cite item
Abstract
A series of previously unreported di- and triaryl(hetaryl)cyclopentenone derivatives were prepared using a convenient synthetic method and screened preliminarily for antitumor activity in four human cell lines, i.e., T-cell leukemia (Jurkat), lung adenocarcinoma (A-549), colon cancer (HCT-116), and breast adenocarcinoma (MCF-7). The most cytotoxic of the tested compounds was 2-(3,4,5-trimethoxyphenyl)-3-(4-methoxyphenyl) cyclopent-2-en-1-one. However, it was inactive against lymphocytic leukemia P388 in mice despite its cytotoxicity in in vitro tests.
About the authors
V. Z. Shirinyan
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: shir@ioc.ac.ru
Russian Federation, 47 Leninskii Prosp, Moscow, 119991
A. I. Markosyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shir@ioc.ac.ru
Armenia, 26 Azatutyan Pr., 0014, Yerevan, 375014
M. A. Baryshnikova
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Email: shir@ioc.ac.ru
Russian Federation, 23 Kashirskoe Shosse, Moscow, 115478
L. V. Yaminova
D. I. Mendeleev University of Chemical Technology of Russia
Email: shir@ioc.ac.ru
Russian Federation, 9 Miusskaya Pl., Moscow, 125047
A. G. L’vov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: shir@ioc.ac.ru
Russian Federation, 47 Leninskii Prosp, Moscow, 119991
S. A. Gabrielyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shir@ioc.ac.ru
Armenia, 26 Azatutyan Pr., 0014, Yerevan, 375014