Synthesis and Antiproliferative Activity Evaluation of Aryl(Hetaryl)Cyclopentenone Analogs of Combretastatin A-4
- Авторлар: Shirinyan V.1, Markosyan A.2, Baryshnikova M.3, Yaminova L.4, L’vov A.1, Gabrielyan S.2
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Мекемелер:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
- N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- Шығарылым: Том 51, № 10 (2018)
- Беттер: 867-872
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244834
- DOI: https://doi.org/10.1007/s11094-018-1706-8
- ID: 244834
Дәйексөз келтіру
Аннотация
A series of previously unreported di- and triaryl(hetaryl)cyclopentenone derivatives were prepared using a convenient synthetic method and screened preliminarily for antitumor activity in four human cell lines, i.e., T-cell leukemia (Jurkat), lung adenocarcinoma (A-549), colon cancer (HCT-116), and breast adenocarcinoma (MCF-7). The most cytotoxic of the tested compounds was 2-(3,4,5-trimethoxyphenyl)-3-(4-methoxyphenyl) cyclopent-2-en-1-one. However, it was inactive against lymphocytic leukemia P388 in mice despite its cytotoxicity in in vitro tests.
Негізгі сөздер
Авторлар туралы
V. Shirinyan
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: shir@ioc.ac.ru
Ресей, 47 Leninskii Prosp, Moscow, 119991
A. Markosyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shir@ioc.ac.ru
Армения, 26 Azatutyan Pr., 0014, Yerevan, 375014
M. Baryshnikova
N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences
Email: shir@ioc.ac.ru
Ресей, 23 Kashirskoe Shosse, Moscow, 115478
L. Yaminova
D. I. Mendeleev University of Chemical Technology of Russia
Email: shir@ioc.ac.ru
Ресей, 9 Miusskaya Pl., Moscow, 125047
A. L’vov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: shir@ioc.ac.ru
Ресей, 47 Leninskii Prosp, Moscow, 119991
S. Gabrielyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia
Email: shir@ioc.ac.ru
Армения, 26 Azatutyan Pr., 0014, Yerevan, 375014