Synthesis, Spectral Characterization, In Vitro Antibacterial Evaluation and POM Analyses of Palladium(II) Thiocyanate Complexes of Thioamides

Abstract

Palladium(II) thiocyanate complexes of general formula, [PdL₄](SCN)₂, where L = thiourea (Tu), N-methylthiourea (Metu), N,N-dimethylthiourea (Dmtu), tetramethylthiourea (Tmtu), imidazolidine-2-thione (Imt) and thionicotinamide (Tna) were prepared by the reaction of K₂[PdCl₄] with thioamides followed by the addition of Potassium thiocyanate in 1:2:2 molar ratio. The complexes were characterized by elemental analysis, and spectroscopic techniques (IR, ¹H and ¹³C NMR), and were screened for antibacterial activities against four strains of bacteria {Staphylococcus aureus (ATCC 25923), Bacillus subtilis (DSM 3256), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 10197)}. Some of the compounds exhibited signifiacnt antibacterial activity even higher than the standards showing the potential for their use as potent antibacterial agents. POM analyses reveal that the compounds are slightly toxic. Moreover, they have 8 ~ 12 % drug score, which is an important parameter for a compound possessing the drug properties.