Synthesis, Spectral Characterization, In Vitro Antibacterial Evaluation and POM Analyses of Palladium(II) Thiocyanate Complexes of Thioamides
- Autores: Nadeem S.1, Sirajuddin M.2, Ahmad S.3, Yaqub S.1, Ali M.1, Tirmizi S.1, Ali S.1, Hameed A.4
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Afiliações:
- Department of Chemistry, Quaid-i-Azam University
- Department of Chemistry, University of Science & Technology
- Department of Chemistry, Prince Sattam bin Abdulaziz University
- Microbiology Research Laboratory, Department of Microbiology, Quaid-i-Azam University
- Edição: Volume 51, Nº 9 (2017)
- Páginas: 793-799
- Seção: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244806
- DOI: https://doi.org/10.1007/s11094-017-1695-z
- ID: 244806
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Resumo
Palladium(II) thiocyanate complexes of general formula, [PdL4](SCN)2, where L = thiourea (Tu), N-methylthiourea (Metu), N,N-dimethylthiourea (Dmtu), tetramethylthiourea (Tmtu), imidazolidine-2-thione (Imt) and thionicotinamide (Tna) were prepared by the reaction of K2[PdCl4] with thioamides followed by the addition of Potassium thiocyanate in 1:2:2 molar ratio. The complexes were characterized by elemental analysis, and spectroscopic techniques (IR, 1H and 13C NMR), and were screened for antibacterial activities against four strains of bacteria {Staphylococcus aureus (ATCC 25923), Bacillus subtilis (DSM 3256), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 10197)}. Some of the compounds exhibited signifiacnt antibacterial activity even higher than the standards showing the potential for their use as potent antibacterial agents. POM analyses reveal that the compounds are slightly toxic. Moreover, they have 8 ~ 12 % drug score, which is an important parameter for a compound possessing the drug properties.
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Sobre autores
Shafqat Nadeem
Department of Chemistry, Quaid-i-Azam University
Email: saeed_a786@hotmail.com
Paquistão, Islamabad, 45320
Muhammad Sirajuddin
Department of Chemistry, University of Science & Technology
Email: saeed_a786@hotmail.com
Paquistão, KPK, Bannu
Saeed Ahmad
Department of Chemistry, Prince Sattam bin Abdulaziz University
Autor responsável pela correspondência
Email: saeed_a786@hotmail.com
Arábia Saudita, Al-Kharj, 11942
Sadaf Yaqub
Department of Chemistry, Quaid-i-Azam University
Email: saeed_a786@hotmail.com
Paquistão, Islamabad, 45320
Muhammad Ali
Department of Chemistry, Quaid-i-Azam University
Email: saeed_a786@hotmail.com
Paquistão, Islamabad, 45320
Syed Tirmizi
Department of Chemistry, Quaid-i-Azam University
Email: saeed_a786@hotmail.com
Paquistão, Islamabad, 45320
Saqib Ali
Department of Chemistry, Quaid-i-Azam University
Email: saeed_a786@hotmail.com
Paquistão, Islamabad, 45320
Abdul Hameed
Microbiology Research Laboratory, Department of Microbiology, Quaid-i-Azam University
Email: saeed_a786@hotmail.com
Paquistão, Islamabad, 45320