An Accessible Route for the Synthesis of Novel Lignan Derivatives and Their Biological Evaluation
- Authors: Raghavendra K.R.1, Renuka N.2, Kumar K.A.2, Shashikanth S.1
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Affiliations:
- Department of Studies in Chemistry, University of Mysore, Manasagangothri
- Post Graduate Department of Chemistry, Yuvaraja College, University of Mysore
- Issue: Vol 51, No 8 (2017)
- Pages: 661-669
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244748
- DOI: https://doi.org/10.1007/s11094-017-1671-7
- ID: 244748
Cite item
Abstract
2-(Aryl(thiophen-2-yl)methyl)succinic acids (4a – 4d), 3-(aryl(thiophen-2-yl)methyl)dihydrofuran-2,5-diones (5a – 5d), 7-aryl-4-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-6-carboxylic acids (6a – 6d), and ethyl 7-aryl-4-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-6-carboxylates (7a – 7d) were synthesized via Stobbe condensation of aryl(thiophen-2-yl)methanones and diethyl succinate. The newly synthesized compounds (5a – 5d, 6a – 6d, and 7a - 7d) were screened in vitro for their antimicrobial and antioxidant properties. Compounds 5b, 6d, and 7d exhibited promising antifungal and antibacterial activity against various microorganisms tested. Compounds 7d and 7b showed remarkable DPPH radical scavenging abilities.
Keywords
About the authors
Kanchipura R. Raghavendra
Department of Studies in Chemistry, University of Mysore, Manasagangothri
Email: ajaykkchem@gmail.com
India, Mysore
Nagamallu Renuka
Post Graduate Department of Chemistry, Yuvaraja College, University of Mysore
Email: ajaykkchem@gmail.com
India, Mysore
Kariyappa Ajay Kumar
Post Graduate Department of Chemistry, Yuvaraja College, University of Mysore
Author for correspondence.
Email: ajaykkchem@gmail.com
India, Mysore
Sheena Shashikanth
Department of Studies in Chemistry, University of Mysore, Manasagangothri
Email: ajaykkchem@gmail.com
India, Mysore