An Accessible Route for the Synthesis of Novel Lignan Derivatives and Their Biological Evaluation
- Авторы: Raghavendra K.1, Renuka N.2, Kumar K.2, Shashikanth S.1
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Учреждения:
- Department of Studies in Chemistry, University of Mysore, Manasagangothri
- Post Graduate Department of Chemistry, Yuvaraja College, University of Mysore
- Выпуск: Том 51, № 8 (2017)
- Страницы: 661-669
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244748
- DOI: https://doi.org/10.1007/s11094-017-1671-7
- ID: 244748
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Аннотация
2-(Aryl(thiophen-2-yl)methyl)succinic acids (4a – 4d), 3-(aryl(thiophen-2-yl)methyl)dihydrofuran-2,5-diones (5a – 5d), 7-aryl-4-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-6-carboxylic acids (6a – 6d), and ethyl 7-aryl-4-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-6-carboxylates (7a – 7d) were synthesized via Stobbe condensation of aryl(thiophen-2-yl)methanones and diethyl succinate. The newly synthesized compounds (5a – 5d, 6a – 6d, and 7a - 7d) were screened in vitro for their antimicrobial and antioxidant properties. Compounds 5b, 6d, and 7d exhibited promising antifungal and antibacterial activity against various microorganisms tested. Compounds 7d and 7b showed remarkable DPPH radical scavenging abilities.
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Об авторах
Kanchipura Raghavendra
Department of Studies in Chemistry, University of Mysore, Manasagangothri
Email: ajaykkchem@gmail.com
Индия, Mysore
Nagamallu Renuka
Post Graduate Department of Chemistry, Yuvaraja College, University of Mysore
Email: ajaykkchem@gmail.com
Индия, Mysore
Kariyappa Kumar
Post Graduate Department of Chemistry, Yuvaraja College, University of Mysore
Автор, ответственный за переписку.
Email: ajaykkchem@gmail.com
Индия, Mysore
Sheena Shashikanth
Department of Studies in Chemistry, University of Mysore, Manasagangothri
Email: ajaykkchem@gmail.com
Индия, Mysore