Synthesis and Antiarrhythmic Activity of 1-Benzyl-3,3-Dialkyl-3,4-Dihydroisoquinoline Chlorides

A. G. Mikhailovskii; O. V. Gashkova; I. P. Rudakova; D. A. Peretyagin

doi:10.1007/s11094-017-1651-y

Synthesis and Antiarrhythmic Activity of 1-Benzyl-3,3-Dialkyl-3,4-Dihydroisoquinoline Chlorides

Authors: Mikhailovskii A.G.¹, Gashkova O.V.¹, Rudakova I.P.¹, Peretyagin D.A.¹
Affiliations:
1. Perm State Pharmaceutical Academy
Issue: Vol 51, No 7 (2017)
Pages: 546-549
Section: Article
URL: https://journals.rcsi.science/0091-150X/article/view/244700
DOI: https://doi.org/10.1007/s11094-017-1651-y
ID: 244700

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Abstract

Cyclocondensation of dialkylbenzylcarbinols with benzylcyanides was used to synthesize 1-benzyl-3,3-dialkyl-3,4-dihydroisoquinolines. The hydrochlorides of the compounds synthesized here were tested for antiarrhythmic activity in a calcium chloride model. The maximum antiarrhythmic index (AI) was found with isoquinolines with cycloalkanone fragments such as cyclopentanone and cyclohexanone in position 3, which had AI values of 15.5 and 16.3, three times the corresponding value for lidocaine.