Email this article Synthesis and Antiarrhythmic Activity of 1-Benzyl-3,3-Dialkyl-3,4-Dihydroisoquinoline Chlorides
- Authors: Mikhailovskii A.G.1, Gashkova O.V.1, Rudakova I.P.1, Peretyagin D.A.1
-
Affiliations:
- Perm State Pharmaceutical Academy
- Issue: Vol 51, No 7 (2017)
- Pages: 546-549
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244700
- DOI: https://doi.org/10.1007/s11094-017-1651-y
- ID: 244700
Cite item
Open Access
Access granted
Subscription Access
Abstract
Cyclocondensation of dialkylbenzylcarbinols with benzylcyanides was used to synthesize 1-benzyl-3,3-dialkyl-3,4-dihydroisoquinolines. The hydrochlorides of the compounds synthesized here were tested for antiarrhythmic activity in a calcium chloride model. The maximum antiarrhythmic index (AI) was found with isoquinolines with cycloalkanone fragments such as cyclopentanone and cyclohexanone in position 3, which had AI values of 15.5 and 16.3, three times the corresponding value for lidocaine.
About the authors
A. G. Mikhailovskii
Perm State Pharmaceutical Academy
Author for correspondence.
Email: ajm@perm.ru
Russian Federation, Perm
O. V. Gashkova
Perm State Pharmaceutical Academy
Email: ajm@perm.ru
Russian Federation, Perm
I. P. Rudakova
Perm State Pharmaceutical Academy
Email: ajm@perm.ru
Russian Federation, Perm
D. A. Peretyagin
Perm State Pharmaceutical Academy
Email: ajm@perm.ru
Russian Federation, Perm
