Synthesis and Antiarrhythmic Activity of 1-Benzyl-3,3-Dialkyl-3,4-Dihydroisoquinoline Chlorides
- 作者: Mikhailovskii A.1, Gashkova O.1, Rudakova I.1, Peretyagin D.1
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隶属关系:
- Perm State Pharmaceutical Academy
- 期: 卷 51, 编号 7 (2017)
- 页面: 546-549
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244700
- DOI: https://doi.org/10.1007/s11094-017-1651-y
- ID: 244700
如何引用文章
详细
Cyclocondensation of dialkylbenzylcarbinols with benzylcyanides was used to synthesize 1-benzyl-3,3-dialkyl-3,4-dihydroisoquinolines. The hydrochlorides of the compounds synthesized here were tested for antiarrhythmic activity in a calcium chloride model. The maximum antiarrhythmic index (AI) was found with isoquinolines with cycloalkanone fragments such as cyclopentanone and cyclohexanone in position 3, which had AI values of 15.5 and 16.3, three times the corresponding value for lidocaine.
作者简介
A. Mikhailovskii
Perm State Pharmaceutical Academy
编辑信件的主要联系方式.
Email: ajm@perm.ru
俄罗斯联邦, Perm
O. Gashkova
Perm State Pharmaceutical Academy
Email: ajm@perm.ru
俄罗斯联邦, Perm
I. Rudakova
Perm State Pharmaceutical Academy
Email: ajm@perm.ru
俄罗斯联邦, Perm
D. Peretyagin
Perm State Pharmaceutical Academy
Email: ajm@perm.ru
俄罗斯联邦, Perm