Synthesis and Biological Activity of Quinoline-2-Carboxylic Acid Aryl Esters and Amides
- Authors: Boyarshinov V.D.1, Mikhalev A.I.1, Yushkova T.A.1, Ukhov S.V.1, Kon’shina T.M.1
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Affiliations:
- Perm State Pharmaceutical Academy, Ministry of Health of Russia
- Issue: Vol 51, No 5 (2017)
- Pages: 351-354
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244605
- DOI: https://doi.org/10.1007/s11094-017-1613-4
- ID: 244605
Cite item
Abstract
Derivatives of quinoline-4-carboxylic acid are known to possess anti-inflammatory and analgesic activity. However, structurally analogous amides and esters of quinoline-2-carboxylic acid are insufficiently studied. In the present work, esters and substituted amides of quinoline-2-carboxylic acid were prepared by reacting quinoline-2-carboxylic acid chloride with phenol or arylamine, respectively. The structures of the synthesized compounds were confirmed using spectroscopic data; the purities, TLC. The physicochemical properties of the target reaction products were determined. Animal experiments determined the anti-inflammatory and analgesic activities as compared with the standard drug diclofenac sodium. The developed method for synthesizing quinoline-2-carboxylic acid derivatives could be used in preparative organic chemistry to prepare potentially biologically active quinoline derivatives.
About the authors
V. D. Boyarshinov
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: perm@pfa.ru
Russian Federation, 2 Polevaya St, Perm, 614990
A. I. Mikhalev
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: perm@pfa.ru
Russian Federation, 2 Polevaya St, Perm, 614990
T. A. Yushkova
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: perm@pfa.ru
Russian Federation, 2 Polevaya St, Perm, 614990
S. V. Ukhov
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: perm@pfa.ru
Russian Federation, 2 Polevaya St, Perm, 614990
T. M. Kon’shina
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Author for correspondence.
Email: perm@pfa.ru
Russian Federation, 2 Polevaya St, Perm, 614990