Synthesis and Biological Activity of Quinoline-2-Carboxylic Acid Aryl Esters and Amides
- 作者: Boyarshinov V.1, Mikhalev A.1, Yushkova T.1, Ukhov S.1, Kon’shina T.1
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隶属关系:
- Perm State Pharmaceutical Academy, Ministry of Health of Russia
- 期: 卷 51, 编号 5 (2017)
- 页面: 351-354
- 栏目: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244605
- DOI: https://doi.org/10.1007/s11094-017-1613-4
- ID: 244605
如何引用文章
详细
Derivatives of quinoline-4-carboxylic acid are known to possess anti-inflammatory and analgesic activity. However, structurally analogous amides and esters of quinoline-2-carboxylic acid are insufficiently studied. In the present work, esters and substituted amides of quinoline-2-carboxylic acid were prepared by reacting quinoline-2-carboxylic acid chloride with phenol or arylamine, respectively. The structures of the synthesized compounds were confirmed using spectroscopic data; the purities, TLC. The physicochemical properties of the target reaction products were determined. Animal experiments determined the anti-inflammatory and analgesic activities as compared with the standard drug diclofenac sodium. The developed method for synthesizing quinoline-2-carboxylic acid derivatives could be used in preparative organic chemistry to prepare potentially biologically active quinoline derivatives.
作者简介
V. Boyarshinov
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: perm@pfa.ru
俄罗斯联邦, 2 Polevaya St, Perm, 614990
A. Mikhalev
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: perm@pfa.ru
俄罗斯联邦, 2 Polevaya St, Perm, 614990
T. Yushkova
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: perm@pfa.ru
俄罗斯联邦, 2 Polevaya St, Perm, 614990
S. Ukhov
Perm State Pharmaceutical Academy, Ministry of Health of Russia
Email: perm@pfa.ru
俄罗斯联邦, 2 Polevaya St, Perm, 614990
T. Kon’shina
Perm State Pharmaceutical Academy, Ministry of Health of Russia
编辑信件的主要联系方式.
Email: perm@pfa.ru
俄罗斯联邦, 2 Polevaya St, Perm, 614990