Hemocoagulation Activity of Sulfur-Containing Pinane-Type Terpenoids
- Authors: Kiselev S.V.1, Nikitina L.E.1, Startseva V.A.1, Artemova N.P.1, Bodrov A.V.1, Boichuk S.V.1, Vorontsova M.M.2, Rakhmatullina A.A.2, Turaev R.G.2, Klochkov V.V.3
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Affiliations:
- Kazan State Medical University
- Republican Hematology Center
- Kazan (Volga Region) Federal University
- Issue: Vol 51, No 5 (2017)
- Pages: 343-347
- Section: Search for New Drugs
- URL: https://journals.rcsi.science/0091-150X/article/view/244602
- DOI: https://doi.org/10.1007/s11094-017-1611-6
- ID: 244602
Cite item
Abstract
A series of pinane-type sulfides and sulfoxides were synthesized from (1S)-(–)-β-pinene. Their hemocoagulation activity in vitro on human blood plasma was studied. All tested compounds exhibited antiaggregation and anticoagulation activity. The most water-soluble sulfoxide with a mercaptoacetic acid moiety inhibited spontaneous platelet aggregation and that induced by collagen and arachidonic acid and also reduced the coagulation activity of human blood plasma. The hemocoagulation activity was due to selective inhibition of platelet receptors, decreased yield of thrombocytic microvesicles, and suppression of their activity.
About the authors
S. V. Kiselev
Kazan State Medical University
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420012
L. E. Nikitina
Kazan State Medical University
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420012
V. A. Startseva
Kazan State Medical University
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420012
N. P. Artemova
Kazan State Medical University
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420012
A. V. Bodrov
Kazan State Medical University
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420012
S. V. Boichuk
Kazan State Medical University
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420012
M. M. Vorontsova
Republican Hematology Center
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420140
A. A. Rakhmatullina
Republican Hematology Center
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420140
R. G. Turaev
Republican Hematology Center
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420140
V. V. Klochkov
Kazan (Volga Region) Federal University
Email: chem@folium.ru
Russian Federation, Kazan, Tatarstan, 420008