Polymeric Complexes of Ofloxacin and Their Activity Against Tuberculosis Mycobacteria

Abstract

The available oral forms of the antituberculosis drug ofloxacin do not ensure its long-term supply to the blood system. New polymeric complexes of ofloxacin based on copolymers of N-vinylpyrrolidone and 2-aminoethyl methacrylate hydrochloride with molecular masses of 25,000 – 87,000 were obtained with the purpose of creating effective prolonged release forms of ofloxacin. The polymeric complexes contained 25 – 35% ofloxacin, exhibited high activity against Mycobacterium tuberculosis H₃₇Rv, and ensured gradual release of ofloxacin (45 – 57% in 50 h) in pH 2.0 buffer at 37°C.