Polymeric Complexes of Ofloxacin and Their Activity Against Tuberculosis Mycobacteria
- Авторы: Solovskii M.1,2, Borisenko M.1,2, Vlasova E.2, Tarabukina E.2, Zakharova N.2, Prazdnikova T.2
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Учреждения:
- Peter the Great St. Petersburg Polytechnic University
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- Выпуск: Том 51, № 4 (2017)
- Страницы: 250-253
- Раздел: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244556
- DOI: https://doi.org/10.1007/s11094-017-1592-5
- ID: 244556
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Аннотация
The available oral forms of the antituberculosis drug ofloxacin do not ensure its long-term supply to the blood system. New polymeric complexes of ofloxacin based on copolymers of N-vinylpyrrolidone and 2-aminoethyl methacrylate hydrochloride with molecular masses of 25,000 – 87,000 were obtained with the purpose of creating effective prolonged release forms of ofloxacin. The polymeric complexes contained 25 – 35% ofloxacin, exhibited high activity against Mycobacterium tuberculosis H37Rv, and ensured gradual release of ofloxacin (45 – 57% in 50 h) in pH 2.0 buffer at 37°C.
Об авторах
M. Solovskii
Peter the Great St. Petersburg Polytechnic University; Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: chem@folium.ru
Россия, St. Petersburg, 195251; 31 Bol’shoi Prosp., St. Petersburg, 199004
M. Borisenko
Peter the Great St. Petersburg Polytechnic University; Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: chem@folium.ru
Россия, St. Petersburg, 195251; 31 Bol’shoi Prosp., St. Petersburg, 199004
E. Vlasova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: chem@folium.ru
Россия, 31 Bol’shoi Prosp., St. Petersburg, 199004
E. Tarabukina
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: chem@folium.ru
Россия, 31 Bol’shoi Prosp., St. Petersburg, 199004
N. Zakharova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: chem@folium.ru
Россия, 31 Bol’shoi Prosp., St. Petersburg, 199004
T. Prazdnikova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: chem@folium.ru
Россия, 31 Bol’shoi Prosp., St. Petersburg, 199004