Synthesis of N-Substituted (2,3-Dihydro-1,4-Benzodioxin-6-YL)Benzenesulfonamide Derivatives as Potent Antibacterial Agents and Moderate Enzyme Inhibitors
- Authors: Abbasi M.A.1, Farani S.K.1, Aziz-ur-Rehman 1, Siddiqui S.Z.1, Ahmad I.2, Malik R.2, Ashraf M.3, Qurat-ul-Ain 3
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Affiliations:
- Department of Chemistry, Government College University
- Department of Pharmacy, The Islamia University of Bahawalpur
- Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur
- Issue: Vol 51, No 3 (2017)
- Pages: 193-199
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244529
- DOI: https://doi.org/10.1007/s11094-017-1581-8
- ID: 244529
Cite item
Abstract
The present research work involved the reaction of 2,3-dihydro-1,4-benzodioxin-6-amine (1) and benzenesulfonyl chloride (2) under dynamic pH control at 10 using aqueous Na2CO3. This reaction yielded 2,3-dihydro-1,4-benzodioxin-6-yl)benzenesulfonamide (3), which was further substituted at N-position with various alkyl/aryl halides (4a – 4m) in N,N-dimethylformamide and catalytic amount of lithium hydride to obtain N-substituted (2,3-dihydro-1,4-benzodioxin-6-yl)benzenesulfonamides (5a – 5m). The projected structures of the synthesized derivatives were confirmed using various spectral techniques (IR, 1H NMR and EIMS). The synthesized derivatives were screened for antibacterial potential and inhibitory activity against lipoxygenase enzyme.
About the authors
M. A. Abbasi
Department of Chemistry, Government College University
Author for correspondence.
Email: atrabbasi@yahoo.com
Pakistan, Lahore, 54000
S. K. Farani
Department of Chemistry, Government College University
Email: atrabbasi@yahoo.com
Pakistan, Lahore, 54000
Aziz-ur-Rehman
Department of Chemistry, Government College University
Email: atrabbasi@yahoo.com
Pakistan, Lahore, 54000
S. Z. Siddiqui
Department of Chemistry, Government College University
Email: atrabbasi@yahoo.com
Pakistan, Lahore, 54000
I. Ahmad
Department of Pharmacy, The Islamia University of Bahawalpur
Email: atrabbasi@yahoo.com
Pakistan, Bahawalpur, 63100
R. Malik
Department of Pharmacy, The Islamia University of Bahawalpur
Email: atrabbasi@yahoo.com
Pakistan, Bahawalpur, 63100
M. Ashraf
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur
Email: atrabbasi@yahoo.com
Pakistan, Bahawalpur, 63100
Qurat-ul-Ain
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur
Email: atrabbasi@yahoo.com
Pakistan, Bahawalpur, 63100