Synthesis of N-Substituted (2,3-Dihydro-1,4-Benzodioxin-6-YL)Benzenesulfonamide Derivatives as Potent Antibacterial Agents and Moderate Enzyme Inhibitors
- Авторлар: Abbasi M.1, Farani S.1, Aziz-ur-Rehman 1, Siddiqui S.1, Ahmad I.2, Malik R.2, Ashraf M.3, Qurat-ul-Ain 3
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Мекемелер:
- Department of Chemistry, Government College University
- Department of Pharmacy, The Islamia University of Bahawalpur
- Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur
- Шығарылым: Том 51, № 3 (2017)
- Беттер: 193-199
- Бөлім: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244529
- DOI: https://doi.org/10.1007/s11094-017-1581-8
- ID: 244529
Дәйексөз келтіру
Аннотация
The present research work involved the reaction of 2,3-dihydro-1,4-benzodioxin-6-amine (1) and benzenesulfonyl chloride (2) under dynamic pH control at 10 using aqueous Na2CO3. This reaction yielded 2,3-dihydro-1,4-benzodioxin-6-yl)benzenesulfonamide (3), which was further substituted at N-position with various alkyl/aryl halides (4a – 4m) in N,N-dimethylformamide and catalytic amount of lithium hydride to obtain N-substituted (2,3-dihydro-1,4-benzodioxin-6-yl)benzenesulfonamides (5a – 5m). The projected structures of the synthesized derivatives were confirmed using various spectral techniques (IR, 1H NMR and EIMS). The synthesized derivatives were screened for antibacterial potential and inhibitory activity against lipoxygenase enzyme.
Авторлар туралы
M. Abbasi
Department of Chemistry, Government College University
Хат алмасуға жауапты Автор.
Email: atrabbasi@yahoo.com
Пәкістан, Lahore, 54000
S. Farani
Department of Chemistry, Government College University
Email: atrabbasi@yahoo.com
Пәкістан, Lahore, 54000
Aziz-ur-Rehman
Department of Chemistry, Government College University
Email: atrabbasi@yahoo.com
Пәкістан, Lahore, 54000
S. Siddiqui
Department of Chemistry, Government College University
Email: atrabbasi@yahoo.com
Пәкістан, Lahore, 54000
I. Ahmad
Department of Pharmacy, The Islamia University of Bahawalpur
Email: atrabbasi@yahoo.com
Пәкістан, Bahawalpur, 63100
R. Malik
Department of Pharmacy, The Islamia University of Bahawalpur
Email: atrabbasi@yahoo.com
Пәкістан, Bahawalpur, 63100
M. Ashraf
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur
Email: atrabbasi@yahoo.com
Пәкістан, Bahawalpur, 63100
Qurat-ul-Ain
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur
Email: atrabbasi@yahoo.com
Пәкістан, Bahawalpur, 63100